- The purpose of this unit is to study molecules involved in respiration. The main emphasis will be on the basis of the cooperative binding of oxygen to hemoglobin. We will intentionally examine events at the level of individual atoms.
NOTE: the following links were updated on
Monday, October 8, 2001 at 8:15 PM
- Look at the following Web materials. Although somewhat redundent, each is brief and together they build up a nice picture. They are listed in the order that I think is most useful
- Concise overview of the physiology of hemoglobin and why cooperativity is important.
- Simple views, A and B, of the basic hemoglobin molecule, to orient you.
- Clear presentation of the movements in hemoglobin associated with cooperativity.
- Five animated, diagrammatic presentation of the movements in detail: 1, 2, 3, 4, 5
- Excellent diagrams of all important atomic interactions.
- See the molecule constructed a piece at a time.
- Still another structure/function presentation.
- Simple pictures of blood cells.
- Slides on structural basis of regulation, and structural varients.
- Text-based presentation of differences in adult, fetal and sickle hemoglobin.
- READING DOWNLOADS for detailed class discussion:
Manning et al. Normal and Abnormal subunits. JBC 273:19359-62 (1998)
Vasquez at al. Cysteines 93 and 112... Biophysical J 76:88-97 (1999)
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